منابع مشابه
Extrapolation from mouse to man.
Despite the above caveat, the impressive new technology described by Gupta et al1 in this issue of Circulation: Cardiovascular Imaging should help to resolve a number of issues relative to the hypothesis that the failing heart is energy starved and that depressed high-energy phosphate flux through the creatine kinase (CK) system is a causative factor.2,3 It will allow longitudinal measurements ...
متن کاملExtrapolation of experimental data from animals to man.
Conditions for extrapolating toxicologic data from animals to man were studied. In the search for general regularities associated with the comparative sensitivity of humans and various species of animals to toxins, it was shown that the toxicity parameters of compounds and the biological constants of mammals correlate with body weight. This relationship is well described by a rectilinear regres...
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Atherosclerosis is a progressive arterial disease characterized by intimal thickening from the accumulation of lipids [1], smooth muscle cells, lipid-filled macrophages, monocytes, lymphocytes, erythrocytes, platelets [2–4] and extracellular matrix proteins (collagen, elastin, proteo glycans) [5,6]. It is considered the major contributor to the development of cardiovascular disease, the leading...
متن کاملExtrapolation of carcinogenic risk from animal experiments in man.
When estimating the absolute risk of cancer, the shape of the dose--response curve in the region of doses where actual exposure of man occurs is of crucial importance. This shape is equally important for the determination of relative risks, as in the comparison of risks from alternative energy sources. Experimental and epidemiological studies are, for various reasons, unable to give sufficientl...
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S tem cell therapy has undergone a rapid translation from bench research to clinical trials as a promising approach for the regeneration of the injured myocardium. 1,2 Magnetic resonance imaging (MRI) plays a pivotal role in the assessment of stem cell therapy efficacy and elucidation of the mechanisms behind therapeutic effects. 3 One important aspect of stem cell therapy, however, remains mis...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Imaging
سال: 2011
ISSN: 1941-9651,1942-0080
DOI: 10.1161/circimaging.110.961979